Fibroblast growth factor 15 (Fgf15) deficiency induces cholesterol and lipid accumulation. Graphic representation of the effect of vertical sleeve gastrectomy (VSG) in Fgf15-deficient mice. CHOP, CCAAT enhancer-binding protein homologous protein; Cyp, cytochrome P-450; ER, endoplasmic reticulum; NTCP, Na+-taurocholate-cotransporting polypeptide; OATP, organic anion transporter polypeptide.