Fig. 7.

15-Hydoxyprostaglandin dehydrogenase inhibitor pretreatment mitigates renal dysfunction after renal ischemia-reperfusion injury (IRI). A: experimental setup for the three different injection protocols. Mice were injected with vehicle or SW033291 (5 mg/kg) according to three different injection protocols. Renal function was assessed at 24 h after renal IRI. B−D: serum levels of blood urea nitrogen (BUN; B), creatinine (C), neutrophil gelatinase-associated lipocalin (NGAL; D), and kidney injury molecule-1 (KIM-1; E). n = 9–11 animals/group. F: renal blood flow. Data are presented as means ± SE. Analysis was performed with Student’s t test.