Fig. 8.

Pretreatment with a single dose of 15-hydoxyprostaglandin dehydrogenase inhibitor attenuates the increase of PGE₂ level and renal damage after renal ischemia-reperfusion injury (IRI). Shown are expression changes of related factors in renal tissue or serum after ischemic acute kidney injury. A: malondialdehyde (MDA) levels in kidney tissue. B–D: neutrophil gelatinase-associated lipocalin (NGAL; B), kidney injury molecule-1 (KIM-1; C), and creatinine (D) levels in serum. E and F: renal PGE₂ levels (E) and serum PGE₂ levels (F). G and H: EP₄ receptor (G) and A_2A receptor (H) mRNA levels in kidney tissue. n = 4–8 animals/group. Data are presented as means ± SE. Analysis was performed using Student’s t test.