Fig. 1.
Tubular casts in the kidney of Dahl salt-sensitive rats. Dahl salt-sensitive rats develop waxy proteinaceous casts (arrows) in renal tubules following high salt feeding. Two weeks of treatment with 0.1 M NaHCO3 solution limits the formation of these tubular casts in the renal medulla (B) compared with 0.1 M NaCl solution (A). Images are shown at ×10 original magnification. Average cast areas in the renal cortex, outer medulla, and papilla in NaCl-treated (n = 9) and NaHCO3-treated (n = 11) Dahl salt-sensitive rats fed a high-salt diet (8%) are shown in C. Data are expressed as means ± SE. Symbols represent individual animals. PTREATMENT is the result of two-way ANOVA comparing kidney region and treatment. [The figure modified from Ray et al. (113).]