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Effects of loss of functional ERα on the RV transcriptome. A total of 31 differentially expressed genes between female ERαMut PAB and female WT PAB rats. Effects of ERα mutation on female PAB RVs are separated by downregulated (total genes: 20) (A) and upregulated (total genes: 11) genes (B). False discovery rate is <0.05. n = 4 for each of the groups. ERα, estrogen receptor α; ERαMut, loss-of-function mutation of ERα; PAB, pulmonary artery banding; RV, right ventricular; WT, wild type.
