Table 4.
Upregulated genes compared with female WT PAB in female ERαMut PAB
| Category | Symbol | Description | LogFC | FDR |
|---|---|---|---|---|
| Inflammation | Socs3 | Suppressor of cytokine signaling 3 | 1.347 | 0.019 |
| Immunity | Ptx3 | Pentraxin 3 | 3.654 | 0.008 |
| Immunity | Slfn4 | Schlafen 4 | 1.626 | 0.012 |
| ECM remodeling | Timp1 | TIMP metallopeptidase inhibitor 1 | 1.192 | 0.006 |
| Calcium handling | Sln | Sarcolipin | 2.875 | 0.008 |
| Bone formation | Tmem119 | Transmembrane protein 119 | 2.819 | 0.001 |
| Iron homeostasis | Hamp | Hepcidin antimicrobial peptide | 1.918 | 0.001 |
| Metabolism | Hsd11b1 | Hydroxysteroid 11-beta dehydrogenase 1 | 0.625 | 0.026 |
| Metabolism | Gfpt2 | Glutamine-fructose-6-phosphate transaminase 2 | 0.931 | 0.008 |
| MISC | Uap1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.798 | 4.19 E-04 |
| MISC | Atp8b1 | ATPase phospholipid transporting 8 B1 | 0.551 | 0.032 |
n = 4 for each group. ERαMut, loss-of-function mutation of ERα; FC, fold change; FDR, false discovery rate; PAB, pulmonary artery banding; WT, wild type.