Table 1.
Optical mapping and anatomic parameters for each group
| Sham |
TAC |
TAC + CNO |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Parameter | n | n | n | Brown-Forsythe | Sham vs. TAC | TAC vs. TAC + CNO | |||
| Optical mapping | |||||||||
| APD60, ms | |||||||||
| 250 ms PCL | 56.41 (8.470) | 6 | 75.78 (10.82) | 5 | 66.56 (12.92) | 6 | 0.7338 | 0.0108 | 0.1842 |
| 150 ms PCL | 55.30 (6.252) | 7 | 58.52 (2.217) | 5 | 53.36 (6.677) | 6 | 0.4341 | 0.3447 | 0.1516 |
| APDss, ms | 57.90 (6.799) | 7 | 78.27 (7.704) | 5 | 65.46 (10.60) | 7 | 0.5458 | 0.0010 | 0.0220 |
| APD60 restitution vector angle, ° | 189.0 (6.943) | 7 | 202.2 (18.93) | 5 | 190.9 (5.661) | 6 | 0.2435 | 0.0619 | 0.1176 |
| CV at 250 ms PCL, cm/s | 61.00 (12.69) | 6 | 38.95 (4.926) | 5 | 41.78 (5.825) | 6 | 0.1794 | 0.0010 | 0.6017 |
| %Change in number of pixels | 0.09408 (0.4026) | 6 | −19.42 (17.08) | 5 | −0.9820 (1.075) | 5 | 0.0012 | N/A | N/A |
| APD60 vs. DI total percentage, % | |||||||||
| 250 ms PCL | 56.07 (12.88) | 6 | 45.00 (16.78) | 5 | 59.10 (14.00) | 6 | 0.8857 | 0.2274 | 0.1303 |
| 150 ms PCL | 62.66 (12.59) | 7 | 37.28 (12.20) | 5 | 66.46 (11.78) | 6 | 0.8678 | 0.0029 | 0.0013 |
| Anatomy | |||||||||
| Body weight, g | 513.0 (96.49) | 7 | 382.6 (66.58) | 5 | 444.6 (23.17) | 7 | 0.2121 | 0.0054 | 0.1463 |
| LV, mm | 3.159 (0.5132) | 7 | 4.350 (0.2904) | 5 | 3.993 (0.5507) | 7 | 0.5213 | 0.0007 | 0.2251 |
| Septum, mm | 2.334 (0.6166) | 7 | 3.410 (0.3654) | 5 | 3.173 (0.2694) | 7 | 0.3010 | 0.0009 | 0.3822 |
| RV, mm | 1.670 (0.4181) | 7 | 1.714 (0.2990) | 5 | 1.661 (0.3598) | 7 | 0.9492 | 0.8414 | 0.8111 |
Values are means (SD); n, number of samples. Brown-Forsythe test for equal variance P values reported. Planned contrast analysis of Sham vs. TAC and TAC vs. TAC + CNO reported with P values from Fisher’s least significant difference test. APD60, action potential duration at 60% repolarization; APDss, APD at fitted steady state; CV, conduction velocity; DI, diastolic interval; LV, left ventricle; N/A, not applicable; PCL, pacing cycle length; RV, right ventricle. LV, septum, and RV are wall thickness measurements.