Table 2.
Noncoding RNAs that regulate HOX genes and/or are transcribed from HOX loci with impact on breast cancer progression.
| Non-Coding RNA | HOX Gene Affected | Effect On Breast Cancer Cells | Reference |
|---|---|---|---|
| miR-10b | ↓ HOXD10 | ↑ Aggressiveness | [103] |
| miR-7/-218 | ↓ HOXB3 | ⊗ Cell cycle/clone formation | [105] |
| miR-181d-5p | ↓ HOXA5 | ↑ Aggressiveness, promotes EMT | [108] |
| HOTAIR | ↓ HOXD10 | ↑ Invasion/ metastasis | [103] |
| HOXA-AS2 * | NA | ↑ Oncogenic behaviour | [144] |
| HOTTIP | ↑ HOXA | ↑ oncogenic behaviour | [161] |
| HOXD-AS1 (HAGRL) * | NA | ↑ Oncogenic behaviour | [169] |
⊗, Inhibition; ↑, Increase; ↓, Decrease; *, Noncoding RNAs transcribed from HOX genes loci; NA, Not Applicable.