TABLE 1.
Patient characteristics of the training set
| Total training | Exacerbation | No exacerbation | p-value | |
| Patients n | 254 | 37 | 217 | |
| Age years | 66.7±9.3 | 64.9±9.5 | 67.0±9.3 | 0.21 |
| Female | 121 (47.6) | 16 (43.2) | 105 (48.4) | 0.69 |
| Blood eosinophils cells·µL−1 | 0.12 (0.07–0.23) | 0.20 (0.12–0.34) | 0.11 (0.06–0.20) | 0.02 |
| Blood neutrophils cells·µL−1 | 5.83 (4.32–8.26) | 6.60 (4.50–9.88) | 5.74 (4.30–7.70) | 0.27 |
| BMI kg·m−2 | 26.4 (23.4–30.4) | 25.9 (22.7–30.5) | 26.5 (23.5–30.1) | 0.86 |
| Pre-BD FEV1 % pred | 61.2±20.9 | 57.1±21.8 | 61.9±20.7 | 0.24 |
| FEV1/FVC ratio | 0.49±0.14 | 0.45±0.14 | 0.49±0.13 | 0.15 |
| Patients with exacerbations | ||||
| Total | 37 (14.6) | |||
| OCS in the past 3 months n | 7 | |||
| AB in the past 3 months n | 9 | |||
| AB+OCS in the past 3 months n | 12 | |||
| Currently using AB n | 2 | |||
| Currently using OCS n | 6 | |||
| Currently using AB+OCS n | 1 | |||
| Patients with ICS | 157 (61.8) | 29 (78.4) | 128 (59.0) | 0.04 |
| CCQ score | 2.1±1.1 | 2.3±1.1 | 2.0±1.0 | 0.19 |
| CCQ score >3 | 55 (22.6) | 8 (21.6) | 47 (21.7) | 1.00 |
| Smoking history | 0.63 | |||
| Never | 7 (2.8) | 1 (2.7) | 6 (2.8) | |
| Ex | 168 (66.1) | 22 (59.5) | 146 (67.3) | |
| Current | 79 (31.1) | 14 (37.8) | 65 (30.0) | |
| Pack-years | 36 (20–49) | 35 (20–42) | 36 (20–50) | 0.38 |
Data are presented as mean±sd, n (%) or median (interquartile range), unless otherwise stated. BMI: body mass index; pre-BD: pre-bronchodilator; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; OCS: oral corticosteroids; ICS: inhaled corticosteroids; AB: antibiotics; CCQ: Clinical COPD Questionnaire. p-values correspond to comparisons between exacerbation/no exacerbation.