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. 2020 Dec 22;22(1):30. doi: 10.3390/ijms22010030

Figure 3.

Figure 3

Inhibition of mTORC2 reduced surviving fraction and colony-forming ability. Treatment with JR-AB2-011 (50–250 µM) for 48 h decreased the colony-forming ability significantly in melanoma cells over two weeks in a dose-dependent manner (p < 0.002) (A). Representative images (B) show the characteristic morphology of the para-, mero- and holoclones of MelJu. The morphology of the colonies of MelJu altered significantly from the large and rapidly growing holoclone to more miscellaneous meroclones and the small and terminal paraclones in a dose-dependent manner (p < 0.04) (C). Asterisks (* p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001) indicate significance between treatment and control. Scale bar indicates 500 µm.