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. 2020 Dec 22;22(1):29. doi: 10.3390/ijms22010029

Figure 2.

Figure 2

Intracellular uptake mechanisms of GEM and C18GEM in Panc1 parental and Panc1 CSCs. Cell viability analysis of Panc1 parental (P) cells and CSCs treated with 50 μM of GEM or C18GEM for 72 h in 2D conditions in the absence or presence of 10 μM dipyridamole (Dip) (A) or of 10 μM sulfo-N-succinimidyl oleate (SSO) (B) or of 0.5 μM chlorpromazine (CPM) (C) or a combination of SSO and CPM (D). Cell viability was measured by a Resazurin Cell Viability Assay Kit, as described in Materials and Methods. Values are the means (±SE) of at least three independent biological replicates. Statistical legend: p < 0.05 (*), p < 0.01 (**), or p < 0.001 (***), as indicated in figure.