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HSF1, p58, MAPK and AMPK signaling. CDN treatment prevented the age-associated alterations in the HSF1, P38 MAPK, MEF2C, PKAA2, and APMK signaling pathways in the gastrocnemius muscles of 26-month old mice, when compared to vehicle treated mice (n = 8–9 mice/group). Upstream regulator analysis of HSF1, P38 MAPK, MEF2C, and PKAA2, while pathways analysis of AMPK is shown. The solid lines show the known direct effect, while the dashed lines show known indirect effects.
