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. 2010 Aug 12;59(6):503–511. doi: 10.1093/jmicro/dfq063

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© The Author 2010. Published by Oxford University Press on behalf of Japanese Society of Microscopy. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

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Fig. 2 — Representative transmission electron micrographs showing ultrastructural changes in DENV-2-infected C6/36 cells. (a) A low-power image showing a large number of cells in the field with cytoplasmic vacuolation. (b) Profile of single DENV-2-infected C6/36 cell showing reticular meshwork in a cytoplasmic vacuole (vac) and an adjacent vacuole with electron-dense material (arrow). (c) Higher magnification of the same showing the presence of virus particles marked v (shown in red rectangular boxes and indicated with white arrows). M indicates the junction between the vacuoles. N denotes the nucleus of the cells in (b) and (c). D denotes electron-dense granules. (d) Negative stained image of a group of DENV-2 (arrows) detected in supernatant of infected C6/36 cells. The red circle marks a single virus particle showing complete envelope projections. Magnification scale bars are embedded in all micrographs.