Table 1.
IC50 Values of Pt Complexes in A2780 and 2780CP/Cl-16 Ovarian Human Cancer Cell Lines
| Complex | IC50 (uM) | Resistance Factor | |
|---|---|---|---|
| A2780a | 2780CP/Cl-16 | 2780CP/A2780 | |
| Cisplatin | 0.3 | 7.1 | 23.7 |
| Carboplatin | 1.3 | 27 | 20.8 |
| Oxaliplatin | 0.15 | 0.3 | 2.0 |
| 7 | 1.6 | 17 | 10.6 |
| 8 | 1.3 | 10.7 | 8.2 |
| 9 | 0.55 | 0.65 | 1.2 |
| 10 | 0.55 | 0.65 | 1.2 |
a
A2780 and 2780CP/Cl-16 ovarian cancer cell lines represent an isogenic human cancer cell pair that displays multidrug resistance due, in part, to the inability of mutant p53 activation by cisplatin and carboplatin.