Table 2.
Selected polymorphisms of NOS and their characteristics [71,72,73,101,102,118,119,120,121,122,123,124].
| Polymorphism | Isoform | Location | Disease | References |
|---|---|---|---|---|
| rs3782218 | NOS1 | C2637T | ischemic heart disease, hypertension | [118] |
| rs2682826 | NOS1 | C276T | ischemic heart disease | [118] |
| rs2779248 | NOS2 | T278C | type 2 diabetes | [120,121] |
| rs1137933 | NOS2 | C231T | type 2 diabetes | [120,121] |
| Tandem repeat polymorphism (VNTR) | NOS3 | 27-bp VNTR | diabetic nephropathy, acute eccentric resistance exercise, metabolic syndrome, atherosclerosis, coronary artery disease | [101,102,119] |
| rs1799983 | NOS3 | G894T | diabetic nephropathy | [73,102,122] |
| rs2070744 | NOS3 | T786C | diabetic nephropathy | [71,72,102] |
| rs1549758 | NOS3 | C774T | ischemic heart disease, coronary artery disease | [118,123] |
| rs3918226 | NOS3 | C665T | hypertension | [118,124] |