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. 2020 Jun 12;8(6):445–452. doi: 10.1093/gastro/goaa016

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© The Author(s) 2020. Published by Oxford University Press and Sixth Affiliated Hospital of Sun Yat-sen University

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Classification of densities of TILs and IPLs, stained with immunohistochemistry of CD4 and CD8. (A, B) Two levels of CD4⁺ TILs, consisting of Q1, 0/mm²; and Q2, >0/mm². (C–F) Quartiles of CD4⁺ IPLs, consisting of Q1, ≤25/mm²; Q2, >25 and ≤52/mm²; Q3, >52 and ≤110/mm²; and Q4, >110/mm². (G–J) Quartiles of CD8⁺ TILs, consisting of Q1, ≤2/mm²; Q2, >2 and ≤5/mm²; Q3, >5 and ≤10/mm²; and Q4, >10/mm². (K–N) Quartiles of CD8⁺ IPLs, consisting of Q1, ≤26/mm²; Q2, >26 and ≤41/mm²; Q3, >41 and ≤50/mm²; and Q4, >50/mm². TIL, tumor infiltrating lymphocyte; IPL, intratumoral periglandular lymphocyte.