Table 2.
Clinicopathological characteristics and CD8+ T-cell densities in 134 colorectal-cancer tissues
| Characteristic | Total | CD8+ TIL |
CD8+ IPL |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | P * | Q1 | Q2 | Q3 | Q4 | P * | ||
| Sex | 0.583 | 0.504 | |||||||||
| Male | 94 (70.1) | 26 (72.2) | 34 (75.6) | 17 (60.7) | 17 (68.0) | 26 (78.8) | 33 (71.7) | 14 (63.6) | 21 (63.6) | ||
| Female | 40 (29.9) | 10 (27.8) | 11 (24.4) | 11 (39.3) | 8 (32.0) | 7 (21.2) | 13 (28.3) | 8 (36.4) | 12 (36.4) | ||
| Age, years | 0.160 | 0.502 | |||||||||
| <60 | 84 (62.7) | 25 (69.4) | 23 (51.1) | 21 (75.0) | 15 (60.0) | 23 (69.7) | 25 (54.3) | 15 (68.2) | 21 (63.6) | ||
| ≥60 | 50 (37.3) | 11 (30.6) | 22 (48.9) | 7 (25.0) | 10 (40.0) | 10 (30.3) | 21 (45.7) | 7 (31.8) | 12 (36.4) | ||
| Tumor differentiation | 0.375 | 0.025 | |||||||||
| Well | 52 (38.8) | 14 (38.9) | 21 (46.7) | 6 (21.4) | 11 (44.0) | 11 (33.3) | 17 (37.0) | 7 (31.8) | 17 (51.5) | ||
| Moderate | 74 (55.2) | 19 (52.8) | 23 (51.1) | 20 (71.4) | 12 (48.0) | 16 (48.5) | 28 (60.9) | 14 (63.6) | 16 (48.5) | ||
| Poor | 8 (6.0) | 3 (8.3) | 1 (2.2) | 2 (7.2) | 2 (8.0) | 6 (18.2) | 1 (2.1) | 1 (4.6) | 0 (0) | ||
| T stage | 0.561 | 0.530 | |||||||||
| T3 | 99 (73.9) | 26 (72.2) | 36 (80.0) | 17 (60.7) | 20 (80.0) | 24 (72.7) | 36 (78.3) | 14 (63.6) | 25 (75.8) | ||
| T4 | 35 (26.1) | 10 (27.8) | 9 (20.0) | 11 (39.3) | 5 (20.0) | 9 (27.3) | 10 (21.7) | 8 (36.4) | 8 (24.2) | ||
| N stage | < 0.001 | 0.215 | |||||||||
| 0 | 107 (79.9) | 21 (58.3) | 34 (75.6) | 27 (96.4) | 25 (100.0) | 26 (78.8) | 33 (71.7) | 18 (81.8) | 30 (90.9) | ||
| 1 | 27 (20.1) | 15 (41.7) | 11 (24.4) | 1 (3.6) | 0 (0) | 7 (21.2) | 13 (28.3) | 4 (18.2) | 3 (9.1) | ||
| Tumor location | 0.879 | 0.596 | |||||||||
| Upper (10–15 cm) | 12 (8.9) | 3 (8.3) | 5 (11.1) | 2 (7.2) | 2 (8.0) | 4 (12.1) | 1 (2.2) | 3 (13.6) | 4 (12.1) | ||
| Middle (5–10 cm) | 65 (48.5) | 18 (50.0) | 19 (42.2) | 13 (46.4) | 15 (60.0) | 14 (42.4) | 24 (52.2) | 10 (45.5) | 17 (51.5) | ||
| Low (0–5 cm) | 57 (42.6) | 15 (41.7) | 21 (46.7) | 13 (46.4) | 8 (32.0) | 15 (45.5) | 21 (45.6) | 9 (40.9) | 12 (36.4) | ||
| MMR | 0.641 | 0.602 | |||||||||
| dMMR | 10 (7.5) | 2 (5.6) | 4 (8.9) | 1 (3.6) | 3 (12.0) | 2 (6.1) | 2 (4.3) | 2 (9.1) | 4 (12.1) | ||
| pMMR | 124 (92.5) | 34 (94.4) | 41 (91.1) | 27 (96.4) | 22 (88.0) | 31 (93.9) | 44 (95.7) | 20 (90.9) | 29 (87.9) | ||
All values are presented as numbers of patients followed by percentages in parentheses.
*
To assess associations between the ordinal categories of lymphocyte densities with categorical data, the chi-square test was performed. To compare continuous variables, the analysis of variance was performed. We adjusted two-sided α level to 0.007 (= 0.05/7) by simple Bonferroni correction. TIL, tumor-infiltrating lymphocyte; IPL, intratumoral periglandular lymphocyte; Q1 to Q4, quantile 1 (lowest) to quantile 4 (highest); MMR, mismatch repair; dMMR, deficient mismatch repair; pMMR, proficient mismatch repair.