Fig. 3.

Magnitude of myocardial oxygen supply and/or demand imbalance and variation in ischemic threshold based on presence and extent of coronary artery disease. The magnitude and duration of myocardial oxygen supply and/or demand imbalance required to cause myocardial ischemia is heterogenous and related to the presence and extent of coronary artery disease. A young patient with no coronary disease will require a significant physiological stressor to trigger myocardial ischemia. Conversely, an older patient with established coronary artery disease may only need a minor trigger. Individualized assessment is paramount.