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. 2020 Dec 28;16(12):e1009266. doi: 10.1371/journal.pgen.1009266

Fig 4. The contributions of pfcoronin and pfkelch13 to resistance are non-additive.

Fig 4

A. Ring-stage survival assay (RSA) survival percentage for one clone of pfcoronin single mutant (cF5 published previously [17], blue), two clones of pfkelch13 single mutants (cD5 and cE3, green) and two clones of pfcoronin and pfkelch13 double mutants (cG9 and cD11, red) in the Pikine background compared to the wildtype (WT, black). B. Ring-stage survival assay (RSA) survival percentage for one clone of pfcoronin single mutant (cG6, blue), one clone of pfkelch13 single mutant (cB15, green) and two clones of pfcoronin and pfkelch13 double mutants (cE9 and cG7, red) in the 3D7 genetic background compared to the wildtype (WT, black). Each point represents an independent biological replicate and dotted line represents the 1% survival threshold, above which survival is considered resistant. Significance level is indicated by the asterisks, *p<005, **p<0.01, determined using two-tailed Mann-Whitney U test.