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. 2020 Dec 28;16(12):e1009266. doi: 10.1371/journal.pgen.1009266

Fig 5. Mutations in PfCoronin conferring resistance to artemisinin are at opposite ends of the putative actin binding sites.

Fig 5

Structure of WD-40 domain of Plasmodium falciparum generated through SWISS-MODEL homology modeling [22] using the crystal structure of the WD-40 domain of Toxoplasma gondii Coronin (4OZU.pdb) [24], which is 43% identical with 99% coverage to the the WD-40 domain of P. falciparum. The predicted actin binding sites are indicated in orange and conserved actin binding site from mouse coronin 1A (R23) [24] indicated in yellow. The mutations that confer artemisinin resistance [17] are indicated in red.