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. 2020 Dec 28;16(12):e1008520. doi: 10.1371/journal.pcbi.1008520

Fig 2. Macrophage polarization and differentiation pathways in GranSim.

Fig 2

A: Representation of signaling pathways for regulatory macrophages and classification of signals as M1 (inflammatory) or M2 (anti-inflammatory). Every time a macrophage receives a signal on the specific pathway a counter is incremented representing the total stimulation level (e.g. stat1Counter). B: Schematic diagram of criteria for macrophage to myofibroblast transformation (MMT) that were implemented in GranSim following, namely that resting macrophages that have STAT1 and STAT3 signals and are not exposed to Mtb.