Table 1. Probit LD50 calculations and harmonic mean TTD.
| Probit 7-day LD50 (spores) | Probit 14-day LD50 (spores) | SC harmonic mean TTD (days) | ||||||
|---|---|---|---|---|---|---|---|---|
| Route | IN | SC | IN | SC | Dose | 1.0 × 106 | 1.0 × 105 | 1.0 × 103 |
| Sterne WT | 3.2 × 104 | 1.8 × 103 | 3.2 × 104 | 1.8 × 103 | 1.76 (1.47–2.21) | 4.17 (2.53–11.93) | 8.68 (4.45–185.05) | |
| Sterne ΔantC | 1.5 × 104 | 9.7 × 102 | 1.5 × 104 | 9.7 × 102 | 1.67 (1.40–2.05) | 3.90 (2.38–10.91) | 5.92 (3.2–31.84) | |
| Sterne ΔantC/COMP | 3.5 × 105 | 3.2 × 103 | 3.5 × 105 | 9.9 × 102 | 2 (2) | 5.73 (3.53–15.17) | 8.52 (4.92–31.55) | |
IN, intranasal challenge; SC, subcutaneous challenge; TTD, time to death; WT, wild-type.