Figure 1. Prothrombin gene mutation increases the thrombin production leading to a hypercoagulability state.

a- Activated, EPCR- Endothelium Protein C Receptor, TM- Thrombomodulin, II- Prothrombin, V- labile Factor, VII- Stable Factor, VIII-Antihemophilic Factor, IX- Christmas Factor, X-Stuart-Prower Factor, XI- Plasma Thromboplastin Antecedent and XII- Hageman Factor.

Adapted from: step1.medbullets.com/hematology/109066/prothrombin-gene-mutation; www.dreamstime.com/artery-vein-structure-comparison-concept-as-human-circulation-section-blood-vessels-anatomy-close-up-d-illustration-image113607632?fbclid=IwAR01uZBxzajXcCoRMMzXBWPKJpg6D8g9tcrJmZhgdKgXMHsVbk_0zCrZkE8