. 2021 Jan 7;7(2):e650. doi: 10.1097/TXD.0000000000001102

Table 1.

A panel of genetic predictors for transplant outcomes

Reference	Gene	Physiologic function	SNP identifier	Associations with clinical outcomes
Reeves-Daniel et al³⁶Freedman et al^37,38	ApoL1	Trypanosome killing function	rs71785313rs60910145rs73885319	Reduced kidney allograft survival
Tonnerre et al⁴⁷Rohn et al⁴⁸	MICA	Stress-induced protein regulated at the cell surface	rs2596538rs67841474	Anti-MICA sensitization and increased proteinuria in kidney transplant recipients and is a predictor of susceptibility to CMV infection
Eikmans et al⁵²	TLR3	Cell-bound receptor involved in innate immune system	rs3775296	Increased acute kidney allograft rejection
Hwang et al⁶⁴	TLR4	Binds to endogenous ligands released from damaged tissues and exogenous ligands such as lipopolysaccharide	rs10759932	Increased rejection-free survival rate
Eikmans et al⁵²	FCN2	Soluble recognition molecule that can engage apoptotic and necrotic cells	rs7851696	Reduced incidence of severe kidney allograft rejection and graft loss
Steers et al⁵⁶	LIMS1	A minor histocompatibility antigen	rs893403	Increased kidney allograft rejection
Oetting et al²⁷	MIR146A	Modulated Treg and suppression of inflammatory responses	rs2910164	Increased kidney allograft rejection
Moore et al⁵¹	CAV1	Involved in cholesterol transport and transmembrane signaling	rs4730751	Increased kidney allograft failure
Forconi et al⁵⁸	PD-1	Involved in the dysfunction of HIV-specific T cell response and CMV-specific CD8 T cells	rs11568821	Improved kidney allograft survival in recipients from CMV-positive donors
Vu et al⁵⁹	IFN-γ	Involved in immune response to viral and bacterial infections	rs2430561	Increased risk for the CMV infection
Moore et al⁴⁹Woillard et al⁵⁰	ABCB1	An efflux pump for intestinal transport of medications including tacrolimus	rs1045642rs2229109	Increased risk of renal allograft loss
Dessing et al⁶⁰	NLRP3	NOD-like receptor family, pyrin domain containing 3 is a member of inflammasome family with a causal role in several inflammatory disorders	rs35829419rs6672995	Increased acute kidney allograft rejection with rs35829419 andReduced acute kidney allograft rejection with rs6672995
Abdi et al⁶¹Cha et al⁶²	CCR5	Chemokine receptor specific for the proinflammatory chemokines	rs1799987	Increased acute kidney allograft rejection
Abdi et al⁶¹Cha et al⁶²	CCR2	Involved in immune response including monocyte recruitment and T cell proliferation	rs1799864	Increased acute kidney allograft rejection
Park et al⁶⁵	IL2RB	Stimulating T-cell proliferation through complex of IL2RA-IL2RB-IL2	rs228942rs228953	Increased acute kidney allograft rejection episodes
Marshall et al⁶⁶	IL6	A pleiotropic cytokine with proinflammatory and anti-inflammatory properties	rs1800795	Increased acute kidney allograft rejection
Sankaran et al⁶⁸Grinyó et al⁶⁹	IL10	An immunomodulatory cytokine with anti-inflammatory effects	rs1800896	Increased acute kidney allograft rejection
Alakulppi et al⁶⁷Sankaran et al⁶⁸Grinyó et al⁶⁹Sánchez-Fructuoso et al⁹¹	TNF-α	Proinflammatory cytokine	rs1800629	(rs1800629 in Donor and Recipient)Increased acute kidney allograft rejection episodes(rs1800629 in Recipient)Modulates the effect of ATG treatment
Tinckam et al⁷⁰Hueso et al¹⁶⁵	TGF-β	Anti-inflammatory but profibrotic cytokine	rs1982073rs1800471	Reduced risk of late acute kidney allograft rejections with rs1800471 and increased kidney allograft subclinical rejection with rs1982073
Pawlik et al⁷¹	CD 28	A costimulatory molecule involved in T cell-mediated immune response	rs3116496	Increased acute kidney allograft rejection
Golshayan et al⁷²	MBL2	Complement-activating MBL, a soluble pattern recognition receptor	rs7096206 rs5030737 rs1800450 rs1800451	Increased acute kidney allograft rejection
Canossi et al⁶³	CTLA4	CTLA4 transduces signals that inhibit lymphocyte activation	rs231775 rs3087243	Reduced acute kidney allograft rejection with rs231775 and increased acute kidney allograft rejection with rs3087243
Heidenreich et al⁷⁴	Factor II	Prothrombotic factor	rs1799963	Increased acute kidney allograft rejection, especially vascular rejections, and early allograft failure
Heidenreich et al⁷⁴	Factor V Leiden	Prothrombotic factor	rs6025	Increased acute kidney allograft rejection especially vascular rejections
Heidenreich et al⁷⁴	MTHFR	Prothrombotic factor	rs1801133	Increased acute kidney allograft rejection, especially vascular rejections
Cartron et al⁹⁶	FCGR3A	Encodes the IgG Fc receptor	rs396991	Increased risk of infection following Rituximab in recipients of liver transplant

The panel is not exhaustive of all published literature.

ABCB1, ATP binding cassette subfamily B member 1; ApoL1, Apolipoprotein 1; ATG, antithymocyte globulin; CAV1, caveolin-1; CCR, chemokine receptor; CMV, cytomegalovirus; CTLA, cytotoxic T-lymphocyte antigen; IFN-γ, interferon-gamma; IL2RB, IL2 Receptor Beta; MBL, mannose-binding lectin; MICA, MHC class I-related chain A; MiR, microRNA; MTHFR, methylenetetrahydrofolate reductase; NLRP3, NOD-like receptor family, pyrin domain containing 3; SNP, single nucleotide polymorphism; TGF, transforming growth factor; TLR, Toll-Like Receptor; TNF-α, tumor necrosis factor-alpha; Treg, regulatory T cells.