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. 2020 Dec 23;13(1):27. doi: 10.3390/cancers13010027

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Top 10 canonical pathways enriched in progressed vulvar squamous cell carcinoma (progVSCC) compared to disease-free vulvar squamous cell carcinoma (d-fVSCC) tumors, identified by core analysis in Ingenuity Pathway Analysis (IPA). Top 10 canonical pathways enriched by IPA. The vertical orange line represents the threshold p-value (0.05) for pathway’s enrichment. The horizontal axis is the –log (p-value). Pathways predicted to be activated are in orange (based on the Z-scores, the activation scores determined by IPA), and grey bars relate to pathways with no activity pattern available.