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. Author manuscript; available in PMC: 2021 Sep 15.
Published in final edited form as: Immunity. 2020 Jul 23;53(3):581–596.e5. doi: 10.1016/j.immuni.2020.07.002

Figure 2. Treg Cells Transferred Restore Dex-Induced Treatment in Treg-Depleted Mice.

Figure 2.

(A) Foxp3DTR mice were induced for EAE. Dex treatment started at the average score of 2 (i.e., days 13–15, arrows). n = 5–7 for each group.

(B) Foxp3DTR mice (n = 5–6) induced for EAE and treated with DTx or with DTx + Dex as above were transferred with flow cytometry sorted tTreg cells (1×106 cells per recipient).

(C–E) Foxp3DTR mice were immunized with MOG 35–55 (150 μg for C or 300 μg for D), treated with Dex for 3 days (arrows). Mice received 2×106 Foxp3+ flow cytometry sorted iTreg cells together with DTx on day 7. The mice were daily monitored and scored for clinical diseases and survival. n = 3–13 for each group. **p < 0.01; ***p < 0.001, as determined by Mann-Whitney or Kruskal-Wallis nonparametric test. Please also see Figure S3.