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. 2021 Jan 8;7(2):eabd4413. doi: 10.1126/sciadv.abd4413

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Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 4 — (A) Representative 2D class averages of the uncross-linked HDAC-DC-nucleosome complex. (B) Stereo views of cryo-EM reconstruction of HDAC-DC in complex with nucleosome at a resolution of 10.60 Å (left) and ribbon diagrams of the HDAC-DC-nucleosome complex with cryo-EM map (far right). (C) Overlay of HDAC-DC with HDAC-PC observed in the nucleosome-bound complexes. Two nucleosomes (dashed trapezoid) are superimposed. (D) Relative domain movements within one HDAC-PC upon asymmetric dimerization with the other HDAC-PC in the nucleosome-bound state. A surface representation of the constructed model is shown. (E) Overview of recognition of histone H2B, H3, and/or H4 N-terminal tails by two individual HDAC-PCs in the nucleosome-bound HDAC-DC.