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. 2021 Jan 8;7(2):eabd4413. doi: 10.1126/sciadv.abd4413

Fig. 6. Multisubunit class I and II HDAC complexes share a general regulatory mechanism in HDAC activity.

Fig. 6

(A) Ribbon diagrams of the yeast Hda1 HDACD-Hda2 NTD2/CCD2, Hda1 HDACD-Hda3 NTD3, human class I HDAC3 bound to SMRT-DAD (PDB 4A69), and human class I HDAC1 in complex with MTA1 (PDB 4BKX) are illustrated on the basis of superposition. The multiple-sequence alignment of HDAC from the yeast and human is shown. (B) Superposition in stereo of one Hda1 HDACD with the other Hda1 HDACD and class I HDACs (PDB 4A69 and 5THU for HDAC3-SMRT-DAD and HDAC8 G304A-M-344, respectively). The cryo-EM density for Y378 in the active site of Hda1 in complex with Hda3 NTD3 is shown as blue mesh. (C) Schematic representation of the catalytic sites of S. cerevisiae Hda1 HDACD dimer with an acetyl-lysine model.