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. 2020 Dec 17;11:596825. doi: 10.3389/fimmu.2020.596825

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Copyright © 2020 Rotman, Otter, Bleeker, Samuels, Heeren, Roemer, Kenter, Zijlmans, van Trommel, de Gruijl and Jordanova

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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t-SNE plots of PD-L1 and PD-L2 expression and distribution in SCC and AC. Comprehensive flowcytometric analysis on tumor digests of SCC (n = 7, top rows) and AC (n = 3, bottom rows). t-SNE analysis shows four PD-L1 and PD-L2 co-expressing macrophage-like populations, based on CD14 or CD163 positivity and low or absent CD1c expression. No. 1) a large population over-represented in AC with relatively high levels of PD-L1 and PD-L2 and low levels of CD80. No. 2) a small PD-L1⁺PD-L2⁺CD80⁻CD163⁺ M2-like macrophage population present in both SCC and AC. No. 3) most frequent population with high levels of both PD-L1 and PD-L2. In SCC only, high co-expression of CD80. No. 4) a small PD-L1⁺/PD-L2⁺ population in AC with low levels of CD80.