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. 2020 Dec 18;8:621768. doi: 10.3389/fbioe.2020.621768

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Copyright © 2020 Bates, Heidenreich, Fallon, Yao, Yim, Hinds and Anderson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quantification of in vitro coagulation on GFPGER-conjugated PVA samples. Coagulation potential of GFPGER-modified samples was determined by measuring fibrin initiation time, rate of fibrin generation, and activity of coagulation factor XII from static coagulation assays. Fibrin initiation lag times in platelet-poor-plasma in the presence of GFPGER-conjugated PVA samples showed prolonged initiation times on GFPGER-modified samples (A). No difference in rate of fibrin generation on GFPGER-conjugated PVA samples was measured (B). There was no difference in FXIIa produced by GFPGER-conjugated PVA samples, shown as rate of cleavage of a chromogenic substrate, when compared to unmodified (C). Data (n = 3–6) are shown as mean ± SD. Statistical analysis was performed using a one-way ANOVA with Tukey’s HSD post hoc testing. ^∗indicates statistical significance (p < 0.01).