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. 2020 Dec 23;11:605671. doi: 10.3389/fphys.2020.605671

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Copyright © 2020 Oh, Yang, Liu, Jana, Izaddoustdar, Gao, Debi, Kim, Kim, Yang, Kassiri, Lakin and Backx.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heat map and clustering analysis of the tumor necrosis factor (TNF)-dependence of extracellular matrix (ECM)-, integrin-, and cell-cell communication-associated genes in 2 week swim exercised mice. Heat map and cluster analysis of individual genes belonging to ECM-, integrin-, and/or cell-cell communication-associated gene sets that are TNF-dependent (cluster 1) or TNF-independent (cluster 2). Note that all individual genes were enriched in sedentary (Sed) vs. swim mice. TNF-dependent (cluster 1) is: SedWT vs. SwimWT (P < 0.05) and SedKO vs. Swim KO (not P < 0.05). TNF-independent (cluster 2) is: SedWT vs. SwimWT (P < 0.05) and SedKO vs. SwimKO (P < 0.05).