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. 2020 Dec 23;11:605671. doi: 10.3389/fphys.2020.605671

FIGURE 4.

FIGURE 4

Differentially regulated pathways in the atria of 2 day swim exercised wild-type (WT) and tumor necrosis factor (TNF) knockout (KO) mice. (A) Gene set enrichment analysis (GSEA) and enrichment mapping showing clusters of differentially regulated pathways in the left atrial appendage (LAA) between WT 2 day swim (blue dots) and sedentary (red dots) mice. (B) Enrichment map showing clusters of differentially regulated pathways in the LAA of TNF-KO 2 day swim (blue dots) and sedentary (red dots) mice. (C) Enrichment map of the difference of the difference analysis revealing clusters of exercise-induced differentially regulated pathways in WT (blue dots) vs. TNF-KO (orange dots) mice. Only gene sets that form clusters are shown for clarity, with connecting lines indicating gene set overlap. Nominal P-value < 0.05, false discovery rate (FDR) < 0.20.