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. 2020 Dec 23;11:605671. doi: 10.3389/fphys.2020.605671

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Copyright © 2020 Oh, Yang, Liu, Jana, Izaddoustdar, Gao, Debi, Kim, Kim, Yang, Kassiri, Lakin and Backx.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential roles of TNF in exercise-induced transcriptomic remodeling with 2 week swim exercise in the left atrial appendage (LAA) vs. left ventricle (LV). (A) Venn diagram of exercise- and TNF-dependent (i.e., Swim WT vs. swim KO) differentially regulated gene sets in the LAA vs. LV. (B) Gene set enrichment analysis (GSEA) and enrichment mapping showing clusters of TNF-dependent differentially regulated gene sets in the LAA (red dots) and LV (green dots). Gene sets that were TNF-dependent and differentially regulated in both LAA and LV are indicated by yellow dots. Only gene sets that form clusters are shown for clarity. Nominal P-value < 0.05, false discovery rate (FDR) < 0.20.