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. 2020 Dec 16;10:584505. doi: 10.3389/fonc.2020.584505

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Copyright © 2020 Zhou, Su, Zhang, Han, Liu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ETS related gene (ERG) is a key mediator for endothelial cells-induced docetaxel resistance in prostate cancer cells. (A, B) 22Rv1 and C4–2B cells were co-cultured with human umbilical vein endothelial cells (HUVEC) for the indicated days, qPCR and western blot analysis were performed to assess ERG expression. (C) Cell viability of C4–2B cells transfected with ERG and siRNA targeting ERG incubated with the indicated dose of docetaxel for 48h. Western blot was conducted to measure ERG expression. (D, E) The percentage of apoptotic C4–2B and C4-2B-ERG cells treated with 10 nM docetaxel for 48 h. (F) The expression of total/cleaved PARP and caspase-3 in C4–2B and C4-2B-ERG cells treated with docetaxel was determined by western blotting. Data were presented as mean ± SD; **P < 0.01; ***P < 0.001.