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. 2020 Dec 16;10:584505. doi: 10.3389/fonc.2020.584505

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Copyright © 2020 Zhou, Su, Zhang, Han, Liu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic model of the hypothesized mechanism by which endothelial cells promote docetaxel resistance of prostate cancer cells. Endothelial cells co-cultured with prostate cancer cells can secrete FGF2 into the culture media. FGF2 boosts the expression of the ETS related gene (ERG) gene in prostate cancer cells subsequently. ERG protein activates Akt/mTOR signaling pathway contributing to docetaxel resistance in prostate cancer cells ultimately.