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. 2020 Dec 23;11:609271. doi: 10.3389/fendo.2020.609271

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Copyright © 2020 Yip, Fuhlbrigge, Alkhataybeh and Fathman

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differentially expressed genes in the pancreata of AA+ individuals compared to controls. 155 genes (59 upregulated and 96 downregulated) were significantly changed by at least 2-fold in the pancreata of AA+ individuals vs. controls (A). Among these, 48 were changed by >2-fold (B), 19 were changed by <2-fold (C), and 88 were unchanged (D) in the pancreata of T1D patients vs. controls. An additional 28 genes were significantly changed by 1.5 to 2-fold in AA+ vs. controls and >2-fold in T1D vs. controls (E). Gene expression heatmaps of the upregulated (F) and downregulated (G) genes from panels A and E are shown. These genes were further analyzed for biological function (See Supplementary Table 2 and Table 3).