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. 2020 Dec 23;11:609271. doi: 10.3389/fendo.2020.609271

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Copyright © 2020 Yip, Fuhlbrigge, Alkhataybeh and Fathman

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene expression in the pancreata of pre-diabetic 12-week-old NOD mice compared to AA+ individuals. 12 genes were found to be similarly changed in the pre-diabetic pancreata of 12-week-old NOD vs. NOD.B10 control mice and the pancreata of AA+ individuals vs. controls (A) Surprisingly, 4 of these genes were among the biologically relevant genes that we verified by QPCR (Figure 4). Fcgr2b, Clec4d, and Rgs16 were not found to be reduced in the pancreata of NOD mice (B), likely due to the high level of insulitis. Abundant expression of various immune cell markers was observed in the NOD pancreas (C).