Table 4A.
Immune functions associated with differentially expressed genes in AA+ vs. control identified by IPA.
| Diseases or Functions Annotation | p-Value* | Genes |
|---|---|---|
| function of helper T lymphocytes | 1.93E-06 | CRTAM, DUSP1, ICOSLG, IL33, IL4R, NPY1R, RGS16 |
| proliferation of B-1 lymphocytes | 1.71E-04 | FCGR2B, IL33, IL4R |
| function of Th1 cells | 2.89E-04 | CRTAM, DUSP1, NPY1R, RGS16 |
| function of Th2 cells | 3.69E-04 | ICOSLG, IL33, IL4R, RGS16 |
| quantity of IgG2a | 9.03E-04 | CD180, FCGR2B, ICOSLG, IL4R, NPY1R |
| degranulation of leukocytes | 9.07E-04 | FCGR2B, PLD1, PSPH, PTPN20B |
| accumulation of Th2 cells | 1.30E-03 | IL33, RGS16 |
| function of T lymphocytes | 1.41E-03 | CRTAM, DUSP1, ERAP1, ICOSLG, IL33, IL4R, NPY1R, RGS16 |
| quantity of IgG2b | 1.75E-03 | CD180, FCGR2B, ICOSLG, NPY1R |
| induction of leukocytes | 2.44E-03 | CRH, IL33, IL4R, MBP |
| degranulation of mast cells | 3.14E-03 | CRH, DUSP1, FCGR2B, IL4R, PLD1 |
| quantity of interleukin | 3.97E-03 | CLEC4D, CRH, DUSP1, IL4R, NPY1R |
| stimulation of mast cells | 4.12E-03 | CRH, IL33 |
| Th2 immune response | 4.24E-03 | ICOSLG, IL33, IL4R |
| function of immune system | 4.68E-03 | CLEC4D, FCGR2B, ICOSLG, IL4R, NPY1R |
| activation of basophils | 6.07E-03 | FCGR2B, IL33 |
| function of blood cells | 6.67E-03 | CRH, CRTAM, DUSP1, ERAP1, FCGR2B, ICOSLG, IL33, IL4R, NPY1R, PLD1, RGS16, TRPM5 |
| induction of helper T cells | 6.80E-03 | IL33, MBP |
| accumulation of T lymphocytes | 6.82E-03 | DUSP1, ICOSLG, IL33, RGS16 |
| induction of lymphocytes | 7.28E-03 | CRH, IL33, MBP |
| activation of blood cells | 8.05E-03 | C1QTNF1, CD180, CEACAM6, CRH, CRTAM, DUSP1, ERAP1, FCGR2B, GNLY, ICOSLG, IL33, IL4R, MBP, NPY1R |
| infiltration of cells | 8.45E-03 | CRH, DUSP1, EGLN3, FCGR2B, IL33, IL4R, IRX2, MBP, S100B |
| stimulation of phagocytes | 8.78E-03 | CRH, IL33, IL4R |
| function of leukocytes | 8.83E-03 | CRH, CRTAM, DUSP1, ERAP1, FCGR2B, ICOSLG, IL33, IL4R, NPY1R, RGS16, TRPM5 |
| quantity of IgG | 9.17E-03 | CD180, CLEC4D, FCGR2B, ICOSLG, IL4R, NPY1R |
| quantity of lymph node cells | 1.01E-02 | ICOSLG, IL33 |
| activation of leukocytes | 1.08E-02 | CD180, CEACAM6, CRH, CRTAM, DUSP1, ERAP1, FCGR2B, GNLY, ICOSLG, IL33, IL4R, MBP, NPY1R |
| stimulation of leukocytes | 1.08E-02 | CRH, ICOSLG, IL33, IL4R, MBP |
| quantity of immunoglobulin | 1.09E-02 | CD180, CLEC4D, FCGR2B, ICOSLG, IL33, IL4R, NPY1R |
| quantity of dendritic cells | 1.25E-02 | CLEC4D, FCGR2B, GNLY, TRPM5 |
| hypersensitive reaction | 1.26E-02 | CLEC4D, DUSP1, FCGR2B, ICOSLG, IL33, IL4R, MBP, NPY1R, PDK4 |
| stimulation of lymphocytes | 1.35E-02 | CRH, ICOSLG, IL33, MBP |
| quantity of transitional B cells | 1.61E-02 | CD180, NPY1R |
| quantity of lymph follicle | 1.65E-02 | CD180, FCGR2B, ICOSLG, NPY1R |
| inflammation of pancreas | 1.72E-02 | FCGR2B, IL33 |
| maturation of bone marrow-derived dendritic cells | 1.72E-02 | FCGR2B, NPY1R |
| infiltration of leukocytes | 1.77E-02 | CRH, DUSP1, EGLN3, FCGR2B, IL33, IL4R, IRX2, S100B |
| delayed hypersensitive reaction | 1.77E-02 | CLEC4D, FCGR2B, IL4R, NPY1R |
| quantity of cytokine | 1.79E-02 | CLEC4D, CRH, DUSP1, IL4R, NPY1R, SIM1 |
| development of Th2 cells | 1.83E-02 | ICOSLG, IL4R |
| proliferation of mast cells | 1.83E-02 | FCGR2B, IL33 |
| quantity of IgA | 1.88E-02 | FCGR2B, ICOSLG, NPY1R |
| activation of lymphocytes | 1.98E-02 | CD180, CEACAM6, CRTAM, DUSP1, FCGR2B, ICOSLG, IL33, MBP, NPY1R |
*Performed using Fisher’s exact test to measure likelihood that the association between the dysregulated gene set and a related function is due to random association.