Table 1.
Anthropometric, demographic and metabolic features of post-RYGB patients according to glucose profile during the MMTT (Hypo and NoHypo).
| MMTT result | |||
|---|---|---|---|
| Hypo | NoHypo | p value | |
| N (% of total) | 11 (47.8%) | 12 (52.2%) | NA |
| Sex (male/female) | 2/9 | 2/10 | 1.000 |
| Age at surgery (years) | 40.6 (32.5-48.5) | 45.2 (39.0-47.8) | 0.294 |
| History of T2DM before surgery (yes/no) | 0/11 | 3/9 | 0.217 |
| Follow-up time after surgery (years) | 5.1 ± 0.6 | 3.8 ± 0.7 | 0.159 |
| BMI before surgery (kg/m2) | 40.1 ± 1.5 | 41.5 ± 1.6 | 0.527 |
| BMI after surgery (kg/m2) | 27.6 ± 0.7 | 28.5 ± 1.0 | 0.502 |
| %EBMIL (%) | 83.2 ± 4.0 | 81.9 ± 6.1 | 0.864 |
| %TWL (%) | 30.6 ± 2.1 | 31.0 ± 2.1 | 0.884 |
| HbA1c (mmol/mol) | 34.4 ± 1.3 | 35.8 ± 1.0 | 0.365 |
| HbA1c (%) | 5.3 ± 0.1 | 5.4 ± 0.1 | 0.358 |
| HOMA2-B (%) | 77.9 ± 6.7 | 70.1 ± 5.6 | 0.376 |
| HOMA2-S (%) | 144.2 ± 11.6 | 152.3 ± 15.6 | 0.685 |
| HOMA2-IR | 0.8 (0.6-0.8) | 0.6 (0.5-1.0) | 0.618 |
| Self-reported hypoglycemia symptoms (yes/no) | 7/4 | 7/5 | 1.000 |
| Dumping criteria (yes/no) | 11/0 | 10/2 | 0.478 |
Results are presented as mean ± SEM, median (interquartile range) or proportions. MMTT, mixed-meal tolerance test; Hypo, individuals developing a glucose nadir <3.05 mmol/l during the MMTT; NoHypo, subjects with glucose levels ≥3.05 mmol/l during MMTT; T2DM, type 2 diabetes mellitus; BMI, body mass index; EBMIL, excess BMI loss; TWL, total weight loss; HOMA2-B, homeostasis model assessment for β-cell function; HOMA2-S, homeostasis model assessment for insulin sensitivity; HOMA2-IR, homeostasis model assessment for insulin resistance.