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. 2020 Dec 10;11:592818. doi: 10.3389/fendo.2020.592818

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Copyright © 2020 Duan, Ge, Jiang, Zhang, Zhao, Li, Zhang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differentiation screening of natural products in C3H10-T1/2 cells. (A) Schematic view of the targeting strategy for natural product screening. (B) Relative gene mRNA expression in differentiated cells treated with natural products. (C) Structure of diphyllin (1). (D) Relative gene mRNA expression in differentiated cells treated with rosiglitazone and diphyllin. (E) Oil red O staining in differentiated cells treated with rosiglitazone or diphyllin. For oil red O staining, n=1; for mRNA expression, n=2. *p < 0.05 and ***p < 0.001.