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. 2020 Dec 10;11:592818. doi: 10.3389/fendo.2020.592818

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Copyright © 2020 Duan, Ge, Jiang, Zhang, Zhao, Li, Zhang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diphyllin protects mice against high-fat diet-induced obesity. (A) Food intake per mouse treated with diphyllin or vehicle. (n = 3). (B) Body weights of mice treated with diphyllin or vehicle. (n = 6). (C) Lean body mass and fat composition of mice determined by NMR after 5 weeks of treatment. (n = 6). (D) Tissue weights of mice determined by NMR after 5 weeks of treatment. (n = 6). (E, F) Glucose tolerance test (GTT) performed in mice after 4 weeks of treatment. (n = 6). (G) Insulin tolerance test (ITT) performed in mice after 6 weeks of treatment. (n = 6). (H, I, J) Plasma total triglyceride (TG), total cholesterol (TC), and nonesterified fatty acid (NEFA) contents of mice measured after 7 weeks of treatment. (n = 6). *p < 0.05, **p < 0.01, and ***p < 0.001.