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. 2020 Dec 10;11:592818. doi: 10.3389/fendo.2020.592818

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Copyright © 2020 Duan, Ge, Jiang, Zhang, Zhao, Li, Zhang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diphyllin enhances brown/beige thermogenesis and reduces adipocyte size in DIO mice. (A–C) Relative mRNA levels of the indicated genes after diphyllin treatment in iBAT, iWAT and eWAT (n=6). (D–F) Western blot analysis and relative integrated density of UCP1 protein in iBAT, iWAT, and eWAT of DIO mice after treatment (n=6). (G–I) Representative HE staining images and statistical diagram of the cell surface of BAT, iWAT, and eWAT. Scale bar = 100 μm for ×10. *p < 0.05, **p < 0.01, and ***p < 0.001.