Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 7;11:609441. doi: 10.3389/fimmu.2020.609441

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Xu, Chen, Wu, Zhang, Cao and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

NLRP3 inflammasome activation following non-canonical inflammasome activation. The non-canonical inflammasome pathway is mediated by caspase-11 in mouse cell and caspase-4/caspase-5 in a human cell in response to cytoplasmic bacterial lipopolysaccharide (LPS). Caspase-4/5/11 cleaves GSDMD to initiate pyroptosis, thus leads to NLRP3 inflammasome activation. GSDMD and P2X7 receptor/Pannexin-1 have been proposed to mediate potassium efflux, which underlies the mechanism of NLRP3 inflammasome activation following non-canonical inflammasome.