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NLRP3 inflammasome activation following caspase-8 mediated pyroptosis. The NLRP3 inflammasome could also be activated following by caspase-8 mediated pyroptosis. The “apoptotic” caspase-8 cleaves GSDMD and further mediated potassium efflux leading to NLRP3 inflammasome activation in murine macrophages. In contrast, Chen et al. demonstrated the pannexin-1 but not GSDMD mediating potassium efflux contributed to NLRP3 inflammasome activation following caspase-8 mediated pyroptosis.
