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. 2020 Dec 7;11:568440. doi: 10.3389/fimmu.2020.568440

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Copyright © 2020 Liu, Xie, Jiang, Liu, Zhang, Bian and Shi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of ERLIN2 on H1299 cell proliferation and invasion. (A) Interference efficiency of the sh-RNAs in H1299 cells. (B) Downregulation of ERLIN2 inhibited H1299 cell proliferation and viability according to EdU (DAPI represents the number of cells in the field; EdU represents the number of proliferating cells). (C, D) Invasion and migration ability of H1299 cells was decreased after ERLIN2 knockdown according to the Transwell assay and wound healing assay (*P < 0.05, **P < 0.01). (E) Analysis of apoptosis of H1299 cells by flow cytometry. After silencing ERLIN2, the cell cycle of G0/G1 phase was blocked in H1299 cell.