Table 3.
Laboratory measurements and treatment.
| Total | Normal development | Mildly abnormal development | Severe brain injury | p-value* | |
|---|---|---|---|---|---|
| First BG (mg/dl), mean ± SD | 21.4 ± 13.7 (n = 64) |
22.8 ± 12.7 (n = 40) |
24.0 ± 16.3 (n = 12) |
14.1 ± 12.7 (n = 12) |
0.051 |
| Lowest BG (mg/dl), mean ± SD | 18.7 ± 10.6 (n = 81) |
20.6 ± 11.0 (n = 53) |
18.1 ± 8.6 (n = 14) |
12.3 ± 8.6 (n = 14) |
0.022 |
| Lowest BG <20 mg/dl, n (%) | 45 (55.6) (n = 81) |
25 (47.2) (n = 53) |
8 (57.1) (n = 14) |
12 (85.7) (n = 14) |
0.014 |
|
Insulin during hypoglycemia (mU/L), median (IQR) |
12.5 (22) (n = 79) |
13.1 (21) (n = 51) |
15.9 (16) (n = 15) |
6.3 (24) (n = 13) |
0.659 |
| Diazoxide-unresponsive, n (%) | 14 (18.2) (n = 77) |
6 (11.8) (n = 51) |
4 (28.6) (n = 14) |
4 (33.3) (n = 12) |
0.086 |
| Max. i.v. glucose infusion rate (mg/kg/min), mean ± SD | 14.5 ± 3.8 (n = 47) |
13.9 ± 4.0 (n = 29) |
15.4 ± 3.2 (n = 10) |
15.4 ± 3.6 (n = 8) |
0.328 |
|
Insulin/glucose ratio (mU/l/mg/dl),
mean ± SD |
1.6 ± 5.5 (n = 72) |
1.3 ± 5.0 (n = 44) |
1.0 ± 1.2 (n = 15) |
3.4 ± 8.9 (n = 13) |
0.888 |
*Comparison of normal development vs. severe brain injury only. Bold type indicates significant result. n, number; SD, standard deviation; %, percent; IQR, interquartile range; BG, blood glucose; i.v., intravenous.