Table 1.
Beneficial effects of sodium-glucose-transporter 2 (SGLT2) inhibitors and low-protein/plant-based diets.
| Effect | SGLT2 inhibitors | Low-protein/plant-based diet |
|---|---|---|
| Decreased sodium proximal tubular reabsorption | + (14) | + (39) |
| Restoration of the tubuloglomerular feedback | + (15–17) | + (39) |
| Reduction of glomerular hyperfiltration | + (15) | + (39) |
| Restoration of autophagy | + (28, 38) | + (58) |
| Slowing of CKD progression | + (15, 26) | + (41) |
| Reduction of unfavorable cardiovascular outcomes | + (1, 2, 4) | + (47–49) |
| Reduction of proteinuria | + (26) | + (44, 46) |
| Reduction of the acid load | - | + (62) |
| Reduction of phosphate load | - | + (63) |
Present: +. Absent: - (reference).