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. 2020 Nov 30;14:582851. doi: 10.3389/fnins.2020.582851

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Copyright © 2020 Ji, Li, Zhao, Li and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes of brain tissue and neurological function in rats 24 h after I/R or not. (A) A significant increase of Zea Longa scores appeared in I/R and HI/R groups compared to control groups, especially in the latter, and decreased by all inhibitors (n = 10, P < 0.01). (B) The water content of brain tissue increased evidently in I/R and HI/R groups compared to control groups (P < 0.01), and decreased in A, P, O, and D groups when compared to HI/R group (n = 3, P < 0.05 or 0.01). (C) The infarction size of cerebrum tissue in HI/R or I/R group was the first and second largest, separately, and decreased by all inhibitors (n = 3, P < 0.01). ^∗∗ or ^∗ means P < 0.01 or 0.05 versus control, ⁺⁺or ⁺ means P < 0.01 or 0.05 versus I/R group, and ^∧∧ or ^∧ means P < 0.01 or 0.05 versus HI/R group, analyzed by one-way ANOVA and Bonferroni post hoc test.