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. 2020 Nov 30;14:582851. doi: 10.3389/fnins.2020.582851

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Copyright © 2020 Ji, Li, Zhao, Li and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes of IκBα, p-IκBα, and NFκB translocation, IL-1, IL-6, and IL-8 levels in cerebrum tissue in rats 24 h after I/R or not. (A) IκBα levels decreased significantly in all other groups, compared to the C group (P < 0.05 or 0.01). The first and second lowest IκBα levels appeared in the HI/R and I/R groups, respectively (P < 0.01), and increased by all inhibitors (n = 3, P < 0.05 or 0.01). (B) The first and second lowest P-IκBα levels appeared in the HI/R and I/R groups, respectively (P < 0.01). Significant decrease of p-IκBα levels appeared in all inhibitor groups than in the HI/R group, but appeared in A, P, O, and D groups when compared to the I/R group (n = 3, P < 0.05 or 0.01). (C) The blot band demonstrated changes of IκBα, p-IκBα, and CBS protein levels in each group. GAPDH was used as normalized protein. (D) Translocation of NFκB levels into nuclear evidently increased in I/R and HI/R groups compared to control group, and decreased by all inhibitors (n = 3, P < 0.01). The blot band showed changes of Cyto NFκB and Nu NFκB protein levels in each group. GAPDH and Histone H3 were used as normalized protein, separately. (E) The IL-1, IL-6, and IL-8 levels in I/R and HI/R groups significantly increased compared to control groups, especially in the latter, and evidently decreased in A, P, O, and D groups than that in HI/R group and I/R group (n = 3, P < 0.01). ^∗∗ or ^∗ means P < 0.01 or 0.05 versus control, ⁺⁺or ⁺ means P < 0.01 or 0.05 versus I/R group, and ^∧∧ or ^∧ means P < 0.01 or 0.05 versus HI/R group, analyzed by one-way ANOVA and Bonferroni post hoc test.