Figure 2.

Correlation analysis between serum NFL level and clinical parameters in Chinese patients with ALS. (A) Serum NFL level negatively correlated with disease duration (R² = 0.15, P = 0.034); (B) Serum NFL level negatively correlated with diagnostic delay (R² = 0.23, P = 0.016); (C) Serum NFL level negatively correlated with ALSFRS-r (R² = 0.15, P = 0.047); (D) Serum NFL level positively correlated with the disease progression rate (R² = 0.42, P < 0.001). ALS, Amyotrophic lateral sclerosis; ALSFRS-r, Amyotrophic lateral sclerosis functional rating scale revised; NFL, Neurofilament light chain.